解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::To identify loci associated with Alzheimer disease, we conducted a three-stage analysis using existing genome-wide association studies (GWAS) and genotyping in a new sample. In Stage I, all suggestive single-nucleotide polymorphisms (at P<0.001) in a previously reported GWAS of seven independent studies (8082 Alzheime...
journal_title:Molecular psychiatry
pub_type: 杂志文章,meta分析
doi:10.1038/mp.2013.86
更新日期:2014-06-01 00:00:00
abstract::Microdeletions of chromosomal region 2q23.1 that disrupt MBD5 (methyl-CpG-binding domain protein 5) contribute to a spectrum of neurodevelopmental phenotypes; however, the impact of this locus on human psychopathology has not been fully explored. To characterize the structural variation landscape of MBD5 disruptions a...
journal_title:Molecular psychiatry
pub_type: 杂志文章,多中心研究
doi:10.1038/mp.2013.42
更新日期:2014-03-01 00:00:00
abstract::Genetic and environmental components as well as their interaction contribute to the risk of schizophrenia, making it highly relevant to include environmental factors in genetic studies of schizophrenia. This study comprises genome-wide association (GWA) and follow-up analyses of all individuals born in Denmark since 1...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2013.2
更新日期:2014-03-01 00:00:00
abstract::Although inherited DNA sequences have a well-demonstrated role in psychiatric disease risk, for even the most heritable mental disorders, monozygotic twins are discordant at a significant rate. The genetic variation associated with mental disorders has heretofore been based on the search for rare or common variation i...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2013.168
更新日期:2014-02-01 00:00:00
abstract::The goal of this study is to investigate the familial transmission of the spectrum of bipolar disorder in a nonclinical sample of probands with a broad range of manifestations of mood disorders. The sample included a total of 447 probands recruited from a clinically enriched community screening and their 2082 adult li...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2013.116
更新日期:2014-02-01 00:00:00
abstract::Studying genetic determinants of intermediate phenotypes is a powerful tool to increase our understanding of genotype-phenotype correlations. Metabolic traits pertinent to the central nervous system (CNS) constitute a potentially informative target for genetic studies of intermediate phenotypes as their genetic underp...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.183
更新日期:2014-02-01 00:00:00
abstract::Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in healthy controls (HCs) and patients with severe forms of major depression has not been well explored, but could explain risk for cortisol dysregulation. In total, 95 participants were studied: 40 patients with psychotic major depres...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2013.129
更新日期:2014-02-01 00:00:00
abstract::Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental disorder. Genetic loci have not yet been identified by genome-wide association studies. Rare copy number variations (CNVs), such as chromosomal deletions or duplications, have been implicated in ADHD and other neurodevelop...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.161
更新日期:2014-01-01 00:00:00
abstract::The endogenous opioid system, which alleviates physical pain, is also known to regulate social distress and reward in animal models. To test this hypothesis in humans (n=18), we used an μ-opioid receptor (MOR) radiotracer to measure changes in MOR availability in vivo with positron emission tomography during social re...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2013.96
更新日期:2013-11-01 00:00:00
abstract::Hyperactivation of the amygdala following chronic stress is believed to be one of the primary mechanisms underlying the increased propensity for anxiety-like behaviors and pathological states; however, the mechanisms by which chronic stress modulates amygdalar function are not well characterized. The aim of the curren...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.90
更新日期:2013-10-01 00:00:00
abstract::Endocannabinoids and their attending cannabinoid type 1 (CB1) receptor have been implicated in animal models of post-traumatic stress disorder (PTSD). However, their specific role has not been studied in people with PTSD. Herein, we present an in vivo imaging study using positron emission tomography (PET) and the CB1-...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2013.61
更新日期:2013-09-01 00:00:00
abstract::The hypothalamic-pituitary-adrenal (HPA) axis and the inflammatory response system have been suggested as pathophysiological mechanisms implicated in the etiology of major depressive disorder (MDD). Although meta-analyses do confirm associations between depression and these biological systems, effect sizes vary greatl...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.144
更新日期:2013-06-01 00:00:00
abstract::The serotonergic neurons of the dorsal raphe (DR) nucleus in the CNS are involved in fear, anxiety and depression. Depression and anxiety occur quite frequently in postmenopausal women, but estrogen replacement to correct these CNS disorders is at present not favored because estrogen carries with it an increased risk ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.62
更新日期:2013-06-01 00:00:00
abstract::The literature on GWAS (genome-wide association studies) data suggests that very large sample sizes (for example, 50,000 cases and 50,000 controls) may be required to detect significant associations of genomic regions for complex disorders such as Alzheimer's disease (AD). Because of the challenges of obtaining such l...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.81
更新日期:2013-05-01 00:00:00
abstract::Schizophrenia is a chronic, severe and highly complex mental illness. Current treatments manage the positive symptoms, yet have minimal effects on the negative and cognitive symptoms, two prominent features of the disease with critical impact on the long-term morbidity. In addition, antipsychotic treatments trigger se...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.57
更新日期:2013-05-01 00:00:00
abstract::Perturbation of Disrupted-In-Schizophrenia-1 (DISC1) and D-serine/NMDA receptor hypofunction have both been implicated in the pathophysiology of schizophrenia and other psychiatric disorders. In the present study, we demonstrate that these two pathways intersect with behavioral consequences. DISC1 binds to and stabili...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.97
更新日期:2013-05-01 00:00:00
abstract::Serum antibodies against amyloid-β peptide (Aβ) in humans with or without diagnosis of Alzheimer's disease (AD) indicate the possibility of immune responses against brain antigens. In an unbiased screening for antibodies directed against brain proteins, we found in AD patients high serum levels of antibodies against t...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.70
更新日期:2013-03-01 00:00:00
abstract::Unbiased genome-wide screens combined with imaging data on brain function may identify novel molecular pathways related to human cognition. Here we performed a dense genome-wide screen to identify episodic memory-related gene variants. A genomic locus encoding the brain-expressed beta-catenin-like protein 1 (CTNNBL1) ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.148
更新日期:2013-02-01 00:00:00
abstract::Given the manifold ways that depression impairs Darwinian fitness, the persistence in the human genome of risk alleles for the disorder remains a much debated mystery. Evolutionary theories that view depressive symptoms as adaptive fail to provide parsimonious explanations for why even mild depressive symptoms impair ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2012.2
更新日期:2013-01-01 00:00:00
abstract::Stress and exposure to glucocorticoids (GC) during early life render individuals vulnerable to brain disorders by inducing structural and chemical alterations in specific neural substrates. Here we show that adult rats that had been exposed to in utero GCs (iuGC) display increased preference for opiates and ethanol, a...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.126
更新日期:2012-12-01 00:00:00
abstract::Psychotic symptoms occur in ~40% of subjects with Alzheimer's disease (AD) and are associated with more rapid cognitive decline and increased functional deficits. They show heritability up to 61% and have been proposed as a marker for a disease subtype suitable for gene mapping efforts. We undertook a combined analysi...
journal_title:Molecular psychiatry
pub_type: 杂志文章,meta分析,多中心研究
doi:10.1038/mp.2011.125
更新日期:2012-12-01 00:00:00
abstract::Although schizophrenia is generally considered to occur as a consequence of multiple genes that interact with one another, very few methods have been developed to model epistasis. Phenotype definition has also been a major challenge for research on the genetics of schizophrenia. In this report, we use novel statistica...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.108
更新日期:2012-11-01 00:00:00
abstract::Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ~1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated association of genetic variants in expert-curated synaptic gene groups with schizophrenia in 4673 ca...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.117
更新日期:2012-10-01 00:00:00
abstract::The NEO-Five-Factor Inventory divides human personality traits into five dimensions: neuroticism, extraversion, openness, conscientiousness and agreeableness. In this study, we sought to identify regions harboring genes with large effects on the five NEO personality traits by performing genome-wide linkage analysis of...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.97
更新日期:2012-10-01 00:00:00
abstract::High-affinity transporters for norepinephrine (NE) and serotonin (5-HT), which ensure neurotransmitter clearance at the synapse, are the principal targets of widely used antidepressant drugs. Antidepressants targeting these high-affinity transporters, however, do not provide positive treatment outcomes for all patient...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.87
更新日期:2012-09-01 00:00:00
abstract::Polymorphic variants of the dopamine D(4) receptor have been consistently associated with attention-deficit hyperactivity disorder (ADHD). However, the functional significance of the risk polymorphism (variable number of tandem repeats in exon 3) is still unclear. Here, we show that whereas the most frequent 4-repeat ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.93
更新日期:2012-06-01 00:00:00
abstract::There is evidence that obesity-related disorders are increased among people with depression. Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity. This study aimed to investigate the genetic influence of polymorphisms in FTO in relation to body mass ...
journal_title:Molecular psychiatry
pub_type: 杂志文章,meta分析
doi:10.1038/mp.2011.45
更新日期:2012-06-01 00:00:00
abstract::In this article, we review some of the data that contribute to our understanding of the genetic architecture of psychiatric disorders. These include results from evolutionary modelling (hence no data), the observed recurrence risk to relatives and data from molecular markers. We briefly discuss the common-disease comm...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2011.65
更新日期:2012-05-01 00:00:00
abstract::Anxiety and depression are devastating mental illnesses that are a significant public health concern. Selective serotonin-reuptake inhibitors are the first-line treatment strategy for these disorders, which despite being a significant advantage over older treatments, are hampered by a limited efficacy in a significant...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2011.162
更新日期:2012-04-01 00:00:00
abstract::Human neural progenitors from a variety of sources present new opportunities to model aspects of human neuropsychiatric disease in vitro. Such in vitro models provide the advantages of a human genetic background combined with rapid and easy manipulation, making them highly useful adjuncts to animal models. Here, we ex...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.60
更新日期:2012-02-01 00:00:00
abstract::Attention-deficit hyperactivity disorder (ADHD) is typically characterized as a disorder of inattention and hyperactivity/impulsivity but there is increasing evidence of deficits in motivation. Using positron emission tomography (PET), we showed decreased function in the brain dopamine reward pathway in adults with AD...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.97
更新日期:2011-11-01 00:00:00
abstract::Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted ...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2011.37
更新日期:2011-11-01 00:00:00
abstract::Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions i...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.54
更新日期:2011-08-01 00:00:00
abstract::Exposure to severe stressors increases the risk for psychiatric disorders in vulnerable individuals, but can lead to positive outcomes for others. However, it remains unknown how severe stress affects neural functioning in humans and what factors mediate individual differences in the neural sequelae of stress. The amy...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.132
更新日期:2011-06-01 00:00:00
abstract::Attention-deficit/hyperactivity disorder (ADHD) is a common, highly heritable neurodevelopmental syndrome characterized by hyperactivity, inattention and increased impulsivity. To detect micro-deletions and micro-duplications that may have a role in the pathogenesis of ADHD, we carried out a genome-wide screen for cop...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.29
更新日期:2011-05-01 00:00:00
abstract::We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, delusions, disorganized speech and thinking, cognitive impairment,...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.63
更新日期:2011-02-01 00:00:00
abstract::We earlier reported a genome-wide significant linkage to schizophrenia at chromosome 17 that was identified in a single pedigree (C702) consisting of six affected, male siblings with DSM-IV schizophrenia and prominent mood symptoms. In this study, we adopted several approaches in an attempt to map the putative disease...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.96
更新日期:2010-11-01 00:00:00
abstract::Attention-Deficit/Hyperactivity Disorder (ADHD) has a very high heritability (0.8), suggesting that about 80% of phenotypic variance is due to genetic factors. We used the integration of statistical and functional approaches to discover a novel gene that contributes to ADHD. For our statistical approach, we started wi...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2010.6
更新日期:2010-11-01 00:00:00
abstract::Environmental enrichment (EE) is known to have an anxiolytic effect in several animal models; however, the molecular mechanisms underlying these behavioral changes are not understood. In this study, we have shown that the anxiolytic effect of EE is associated with alterations in the corticotropin-releasing factor rece...
journal_title:Molecular psychiatry
pub_type: 杂志文章
doi:10.1038/mp.2009.151
更新日期:2010-09-01 00:00:00
abstract::Bipolar disorder (BPD) is characterized by vulnerability to episodic depression and mania and spontaneous cycling. Because of marked advances in candidate-gene and genome-wide association studies, the list of risk genes for BPD is growing rapidly, creating an unprecedented opportunity to understand the pathophysiology...
journal_title:Molecular psychiatry
pub_type: 杂志文章,评审
doi:10.1038/mp.2010.3
更新日期:2010-09-01 00:00:00